Die Atombombe und die Zukunft des Menschen is the topical title of Karl Jaspers's latest book. His intention is excellent, he wants to arouse the conscience of man in face of the deadly danger of atomic warfare. It would be most interesting to compare this book of more than 500 pages with Bertrand Russell's corresponding short publications which concentrate on practical proposals. In order to do justice to Jaspers the English reader should, however, keep in mind that the author had (...) to overcome formidable obstacles. His subtitle, Politisches Bewusstsein in unserer Zeit, indicates that he does not only wish to discuss the present dangerous situation and the means for mastering it, but also to lay the foundation of a Political Philosophy. But here he is faced with two brute facts. First, the Germans are almost by nature un political and falsify by their existence a famous Aristotelian dictum. Their political sense or instinct is, for complex psychological and historical reasons, underdeveloped; a fact which is, paradoxically, of great political importance. Secondly, a German Political Philosophy in the Anglo-American sense does not exist; it forms part of the Rechts-und Staatsphilosopie or of sociological studies. Consequently, Jaspers has to construct his Political Philosophy on the basis of his own Philosophy of Existence, an interesting experiment, beset with formidable difficulties. Here again he remains the gliding philosopher, whose analysis of our political predicament moves in “possible perspectives” so that in the end everything remains in suspense. Indeed, Jaspers holds that rationally atomic warfare cannot be eliminated and that the total destruction of mankind is probable. He therefore appeals to every human being for a radical change of heart which alone could avert the disaster. This change of the “essence of man” remains a Utopian hope. Nevertheless, Jaspers is right in appealing to everybody's conscience. He confirms, moreover, that his existentialism cannot provide the basis for a Political Philosophy. (shrink)

One of the fundamental differences between English and German civilisation which leads to different philosophical problems is their attitude to the reality of history. The English “live” history as if it were nature. They found at least by the thirteenth century their own form of life, of government, constitution, and state, which have lasted ever since through all changes so that a rich system of traditions has developed. Germany did not find a lasting unity as early as that, but, being (...) divided into many autonomous parts, religions, and tribes, it did not reach a strong social or moral tradition. Consequently the “rise of the historical consciousness“ and even the wish to awaken the nation as a whole to it is in Germany an intellectual product. But what has been a disadvantage in the sphere of politics has been an advantage to science and philosophy. The German even believes it to be one of their chief contributions to the History of Thought that they have developed a scientific history and all the sciences which analyse its field, and above that the “Historism,“ a historical Weltanschauung or the task of interpreting the whole world from the point of view of history. (shrink)

In the March 1982 issue of the Journal Dr Pheby, a community health doctor, was one of several writers to discuss medical confidentiality. Dr Pheby urged doctors to minimise subjective and judgmental comments in medical records and to make clear when their assessments were speculative. He also urged `vigorous reappraisal of the extent to which information about a patient needs to be circulated' to members of other disciplines, for instance, in child health practice. If doctors did not take such steps (...) themselves legal changes might well be imposed upon them, giving patients the right of access to their medical records and perhaps making breach of medical confidentiality a criminal offence. Mr Jacob, a lawyer, commenting on the papers by Dr Pheby and Mr Kenny, a health administrator, argued that increased legal intervention in medical ethics could quite possibly actually erode traditional medical ethical standards of confidentiality based on peer review and `the ethic of virtue'. (shrink)

The argument of this book is that there is a form of Christian philosophy congruent with the contemporary philosophical climate. According to the author, a philosophy is Christian to the extent that it is elaborated within a Christian Weltanschauung, that is, insofar as its spirit and fundamental contents are guided by Christian revelation and bear the impress of Christian redemption. Christian philosophy is not a single system, but rather a tradition which approaches philosophical problems from a Christian perspective. Within this (...) tradition there can exist a considerable variety of philosophical opinion, since Christian revelation leaves many questions undecided. To show that such a Christian philosophy is possible today the author spends the major part of the book surveying a number of currents in recent philosophy. One purpose of this survey is to examine the resources and weaknesses of various philosophical methodologies. More importantly, the survey is used as the basis for arguing that existentialism, phenomenology, and analytic philosophy have recently developed in directions which suggest the possibility of formulating a new metaphysics which is at once contemporary and compatible with Christian philosophy as the author understands it. This new metaphysics is one which steers a middle ground between dogmatism and relativism. It is at once synoptic, in that it seeks a coherent understanding of the whole of reality by filling in the gaps in individual and collective experience; categorial, in that it forges categories which "picture the pervasive and formative characteristics of the world which are indicated by the large-scale structural aspects of experience and language rather than by particular observations or individual terms"; perspectival, in the sense that such a metaphysics elaborates a view of the world judged adapted to the philosopher's basic human commitments, to the empirical facts, and to formal laws of coherence and consistency, but in such a way that it remains open to changing attitudes and insights. Though its basic argument is not hard to grasp, this book is not easy to read. Partially this is due to a rather plodding style, but primarily it is the result of the structure of the book, which is such that the author discourses at a level of considerable generality on the doctrines of a great many different philosophers. He does this partially in order to illustrate his understanding of the dialogical character of philosophy. Nevertheless, the author's aims might well have been better served by a briefer, more sharply honed argument.--H. F. (shrink)

The Tree of Nature represents an IT-based approach to understanding Nature in the light of present-day scientific knowledge. The universe, in this view, consists of discrete entities; these are not material particles, however, but information processing events that produce observable changes in the world. The surprising result of this analysis is that the workings of Nature are based on a decision tree consisting of two dozen parameters. The tree is similar to the evolutionary phylogenetic system of the various forms of (...) life, but it is far more fundamental; constituting, as it does, the very base of everything that exists. The overall conclusion is that the universe is steadily producing new information. Metaphorically speaking, it constitutes a self-unfolding story in which events do not pass away into non-existence but instead remain forever as an indelible part of the whole. This also holds true for integrated sets of events, such as the lifetime experiences of an individual. The Tree of Nature leads to the following testable prediction: A successful quantum-gravity theory will involve the notion of a strong complementarity between gravity and the strong nuclear force. (shrink)

Most of us came into ecology with memories of special personal places. A cliff top that Claude Monet might have painted. Allen as a youth spent his holidays on the Dorset Coast near Swanage; he can still smell the sea breeze of his childhood. Curtin grow up on a farm in southwestern Wisconsin, the dew of the grass and the bright green on a June morning remains vivid. The catching of reptiles and insects for him awakened a curiosity about the (...) natural world that has remained to this day. But once into the field there came the scholarship. With ever tighter grant monies, the pressure to publish takes so much of the fun out of it. A climate of unbridled careerism prevails and shows itself in the incremental state of the literature: little things to list on this year's activities report. There are now even predatory journals that cynically do not seriously review submissions, and only collect page charges. As journal editors have a desperate time getting reviews done by mature scholars, instead of a hand off to their overworked graduate students. So what is to be done - how can we bring the joy and importance of discovery back into it all? After all ecology is done by human beings. Mostly it is a personal mission, for what great ecologists write is frequently personal and life changing. So an undercurrent of this book is to remind and reveal the original purpose of science. Not professional advancement, but the genuine search for novel ideas and the imperative to share hard won insights and personal passions. (shrink)

In describing the flawless regularity of developmental processes and the correlation between changes at certain genetic loci and changes in morphology, biologists frequently employ two metaphors: that genes ‘control’ development, and that genomes embody ‘programs’ for development. Although these metaphors have an admirable sharpness and punch, they lead, when taken literally, to highly distorted pictures of developmental processes. A more balanced, and useful, view of the role of genes in development is that they act as suppliers of the material needs (...) of development and, in some instances, as context‐dependent catalysts of cellular changes, rather than as ‘controllers’ of developmental progress and direction. The consequences of adopting this alternative view of development are discussed. (shrink)

Psychology has a long past, yet its real history is short. For thousands of years it has existed and has been growing older; but in the earlier part of this period it cannot boast of any continuous progress toward a riper and richer development. In the fourth century before our era that giant thinker, Aristotle, built it up into an edifice comparing very favorably with any other science of that time. But this edifice stood without undergoing any noteworthy changes or (...) extensions, well into the eighteenth or even the nineteenth century. Only in recent times do we find an advance, at first slow but later increasing in rapidity, in the development of psychology. The general causes which checked the progress of this science and thus made it fall behind the others can readily be stated:— "The boundaries of the Soul you cannot find, though you pace off all its streets, so deep a foundation has it," runs a sentence of Heraclitus, and it hits the truth more fully than its author could ever have expected. The structures and functions of our mental life present the greatest difficulties to scientific investigation, greater even than those presented by the phenomena, in many respects{4} similar, of the bodily life of the higher organisms. These structures and processes change so unceasingly, are so fleeting, so enormously complex, and dependent on so many factors hidden yet undoubtedly influential, that it is difficult even to seize upon them and describe their true substance, still more difficult to gain an insight into their causal connections and to understand their significance. We are just now beginning to recognize the full force of these difficulties. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Book Reviews St. Auc~stine and Being: A Me$aphyM,cal Essay. By James F. Anderson. (The Hague: Martinus Nijhoff, 1965.Pp. viii [i] + 76. Guilders 9.90.) Contemporary students of medieval philosophy, especially those influenced by the writings of Gilson, usually view Augustine as primarily an essentialist in metaphysics, while Aquinas is viewed as some sort of existentialist. This is taken to mean that, whereas Augustine seems to identify being with essence (...) or wha~ a thing is, Aquinas distinguishes between what a thing is and its act of existence. The major contribution of Aquinas to later philosophy is often depicted as this distinction between essence and existence. Perhaps the major interest and value of Professor Anderson's essay is that it contests this currently predominant opinion of the essentialist character of Augustinian metaphysics and calls for a re-evaluation of the supposedly revohi~ionary character of the Thomistic concentration upon the act of existence. It is quite evident that Augustine broke with Plotinus when he asserted that the first principle of all things was God, being itself (ipsum esse), rather than the One, which transcends being. The controversy arises over Augustine's view of the nature of being (esse). For Gilson the notion of being remained for Augustine Neoplatonic, while for Anderson Augustine introduced an existential aspect to the notion of being lacking in Neoplatonic thought. Citing the same texts for support Gilson maintains that Augustine interprets the name of God given in Exodus as "I am he who never changes," while Anderson maintains that Augustine interprets Exodus as asserting that God is being, in the sense of existence, itself. The major point of disagreement between Gilson and Anderson is not whether Augustine regarded being as pre~ dominant, but how Augustine interpreted the notion of being. In some texts Augustine maintsSns that being and immutability mean the same thing, in others he argues that a thing truly is 'because it is immutable, and in yet others he argues that a thing is immutable because it truly is. The first opinion seems to be the one frequently favored as an interpretation of Augustine by Gilson. The second is usually regarded as Neoplatonic. The third is the opinion which Professor Anderson argues was most accurately Augustine's. According to Professor Anderson the first two opinions reflect for Augustine a merely factual connection between being and immutability, whereas the third reflects a metaphysical entailment. I should like to mention three points in Professor Anderson's discussion which seem to me weak. Firstly, as Augustine remarks that being is the name for unchangeableness we cannot take this as asserting a merely factual relationship. Secondly, to say that 'being' and 'immutability ~mean the same thing to Augustine or that being and immutability are identical to him does not necessitate, as Professor Andersen claims, denying the primacy of being. If 'being' and 'immutability' mean the same thing, then it is very peculiar to ask which is primary. If it is remarked that 'triangleI means the same thing as 'three sided figure', what sense does it make to ask which notion is primary? I suspect that Professor Anderson's contention makes sense only if one believes that there is a difference in the meanings of 'being' and 'immutability ', but whether or not there was such a difference for Augustine is precisely the point at issue. Professor Anderson asserts that it would be a "metaphysical inconsistency" to claim that God is both being and immutability, but it is not clear why such a claim would be inconsistent if the two terms in fact mean the same thing (p. 30). Thirdly, if, as is in fact the case, Augustine's remarks on the relationship between immutability and being are inconsistent perhaps we should accept the possibility that Augustine himself never came to a clear view on this matter rather than attempt to surmise what Augustine "must have meant." Of course, such inconsistency in Augustine's writings would tend to support the thesis of Gilson that Augustine has difficulties reconciling his theology and metaphysics. Moreover, the analogy Professor Anderson suggests between the Augustinian mutability-immutability contrast and the Thomistic potency-act contrast could only be a very rough one... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Book Reviews St. Auc~stine and Being: A Me$aphyM,cal Essay. By James F. Anderson. (The Hague: Martinus Nijhoff, 1965.Pp. viii [i] + 76. Guilders 9.90.) Contemporary students of medieval philosophy, especially those influenced by the writings of Gilson, usually view Augustine as primarily an essentialist in metaphysics, while Aquinas is viewed as some sort of existentialist. This is taken to mean that, whereas Augustine seems to identify being with essence (...) or wha~ a thing is, Aquinas distinguishes between what a thing is and its act of existence. The major contribution of Aquinas to later philosophy is often depicted as this distinction between essence and existence. Perhaps the major interest and value of Professor Anderson's essay is that it contests this currently predominant opinion of the essentialist character of Augustinian metaphysics and calls for a re-evaluation of the supposedly revohi~ionary character of the Thomistic concentration upon the act of existence. It is quite evident that Augustine broke with Plotinus when he asserted that the first principle of all things was God, being itself (ipsum esse), rather than the One, which transcends being. The controversy arises over Augustine's view of the nature of being (esse). For Gilson the notion of being remained for Augustine Neoplatonic, while for Anderson Augustine introduced an existential aspect to the notion of being lacking in Neoplatonic thought. Citing the same texts for support Gilson maintains that Augustine interprets the name of God given in Exodus as "I am he who never changes," while Anderson maintains that Augustine interprets Exodus as asserting that God is being, in the sense of existence, itself. The major point of disagreement between Gilson and Anderson is not whether Augustine regarded being as pre~ dominant, but how Augustine interpreted the notion of being. In some texts Augustine maintsSns that being and immutability mean the same thing, in others he argues that a thing truly is 'because it is immutable, and in yet others he argues that a thing is immutable because it truly is. The first opinion seems to be the one frequently favored as an interpretation of Augustine by Gilson. The second is usually regarded as Neoplatonic. The third is the opinion which Professor Anderson argues was most accurately Augustine's. According to Professor Anderson the first two opinions reflect for Augustine a merely factual connection between being and immutability, whereas the third reflects a metaphysical entailment. I should like to mention three points in Professor Anderson's discussion which seem to me weak. Firstly, as Augustine remarks that being is the name for unchangeableness we cannot take this as asserting a merely factual relationship. Secondly, to say that 'being' and 'immutability ~mean the same thing to Augustine or that being and immutability are identical to him does not necessitate, as Professor Andersen claims, denying the primacy of being. If 'being' and 'immutability' mean the same thing, then it is very peculiar to ask which is primary. If it is remarked that 'triangleI means the same thing as 'three sided figure', what sense does it make to ask which notion is primary? I suspect that Professor Anderson's contention makes sense only if one believes that there is a difference in the meanings of 'being' and 'immutability ', but whether or not there was such a difference for Augustine is precisely the point at issue. Professor Anderson asserts that it would be a "metaphysical inconsistency" to claim that God is both being and immutability, but it is not clear why such a claim would be inconsistent if the two terms in fact mean the same thing (p. 30). Thirdly, if, as is in fact the case, Augustine's remarks on the relationship between immutability and being are inconsistent perhaps we should accept the possibility that Augustine himself never came to a clear view on this matter rather than attempt to surmise what Augustine "must have meant." Of course, such inconsistency in Augustine's writings would tend to support the thesis of Gilson that Augustine has difficulties reconciling his theology and metaphysics. Moreover, the analogy Professor Anderson suggests between the Augustinian mutability-immutability contrast and the Thomistic potency-act contrast could only be a very rough one... (shrink)

Raciolinguistics reveals the central role that language plays in shaping our ideas about race and vice versa. The book brings together a team of leading scholars-working both within and beyond the United States-to share powerful, much-needed research that helps us understand the increasingly vexed relationships between race, ethnicity, and language in our rapidly changing world. Combining the innovative, cutting-edge approaches of race and ethnic studies with fine-grained linguistic analyses, authors cover a wide range of topics including the struggle over the (...) very term "African American," the racialized language education debates within the increasing number of "majority-minority" immigrant communities in the U.S., the dangers of multicultural education in a Europe that is struggling to meet the needs of new migrants, and the sociopolitical and cultural meanings of linguistic styles used in Brazilian favelas, South African townships, Mexican and Puerto Rican barrios in Chicago, and Korean American "cram schools" in New York City, among other sites. Taking into account rapidly changing demographics in the U.S and shifting cultural and media trends across the globe--from Hip Hop cultures, to transnational Mexican popular and street cultures, to Israeli reality TV, to new immigration trends across Africa and Europe--Raciolinguistics shapes the future of scholarship on race, ethnicity, and language. By taking a comparative look across a diverse range of language and literacy contexts, the volume seeks not only to set the research agenda in this burgeoning area of study, but also to help resolve pressing educational and political problems in some of the most contested raciolinguistic contexts in the world. (shrink)

Purpose: Understanding the place of Ernst von Glasersfeld's Radical Constructivism (RC), and some of its implications, in the development of epistemology. Design: Characterization of two main options for the content of "knowledge" (without and with belief in mind-independent structures), sketch of their history in occidental thought; comparison of their properties concerning subjectivity, objectivity, second-order cybernetics, reliability of mental tools, and the needs and mechanisms for certainty and overall structures. Findings: Awareness that we structure mental working tools can, as RC suggests, (...) replace belief in mind-independent reality, and this change dissolves the conceptual problem of metaphysics-ontology, but also eliminates the certainty expected from it, which raises the possibility of relativism. Working-concepts cannot be deconstructed because they imply no ontological claims. Subject(s) are necessarily included in all knowledge (which does not mean solipsism): because subjective experience encompasses all mental tools, including those of objectivity and mathematics, while in contrast the subject itself cannot become an objective system. Practical reliability of mental tools differs from subjective certainty, which requires an ontological leap of faith to positive beliefs: for specific tools including automata, and for positive holistic structures. However, in agreement with the constructivist view, holistic views can instead have an unstructured center, with reliability = viability, which prevents relativism. In sum, belief in mid-independent reality is needed for certainty if desired; for all other purposes constructivism is more helpful. Implications: The change in view suggested by von Glasersfeld's work is of relevance for a number of fields of study with conceptual problems (such as the mind-brain relation). However, due to their generality, the implications will need evaluation in specific instances. The question of certainty needs attention for practical reasons. (shrink)

Many of the commentaries cohere around two major points of criticism. The first is that we have omitted discussion of the mechanisms that are assumed to operate at levels 2, 3, and 4.Campbell, Cloak, Dewsbury, Eckberg, Mundinger, Pulliam, Richerson & Boyd, Slobodkin, Simon, Williams, andWahlstenall make comments that bear on this point. The second point is that we have omitted discussion of the fact that "organisms change the environment by their activities" and thereby modify the selection pressures that act on (...) them. Apart from Lewontin, this point has been raised in different forms byBarkow, Chase, Hull, Perzigian, Ruyle, and less directly bySlobodkin. Stemming from these two basic omissions there is a third general criticism. Numerous commentators have pointed out that we have failed to discuss sufficiently either the extent or nature of the constraints that may or may not be operating on supraordinate evolutionary processes as a function of their nested relationships to subordinate evolutionary processes within our scheme. We start by acknowledging these three basic omissions. We agree that they exist and that they are serious. (shrink)

If we are to ensure the persistence of species in an increasingly warm world, of interest is the identification of drivers that affect the ability of an organism to resist thermal stress. Underpinning any organism's capacity for resistance is a complex interplay between biological and physical factors occurring over multiple scales. Tropical coral reefs are a unique system, in that their function is dependent upon the maintenance of a coral–algal symbiosis that is directly disrupted by increases in water temperature. A (...) number of physical factors have been identified as affecting the biological responses of the coral organism under broadscale thermal anomalies. One such factor is water flow, which is capable of modulating both organismal metabolic functioning and thermal environments. Understanding the physiological and hydrodynamic drivers of organism response to thermal stress improves predictive capabilities and informs targeted management responses, thereby increasing the resilience of reefs into the future. (shrink)

Each generation finds new significances in its own past. Historians tend to reflect in new preoccupations the interests of their own day. Hence, in an age when we are conscious of the significance of science, it is understandable that the history of science should come increasingly into prominence. Histories of science have existed since the nineteenth century—it was Comte, apparently, who coined the phrase ‘the Scientific Revolution ’—but they have been written on comparatively unsophisticated lines by scientists, turned historian in (...) the ‘sere and yellow’. To-day the position is very different. General histories of science exist in plenty and of a quality higher than any political histories of a similar kind. Journals devoted to the history of science also find a ready audience and conferences take place at regular intervals. The volume under review is the record of a conference held at Oxford in 1961 under the general heading ‘Scientific Change’, with special reference to the intellectual, social and technical conditions for scientific discovery and technical invention. (shrink)

Applying the sensemaking perspective in the field of corporate social responsibility is a recent but promising development. Using an in-depth exploratory case study, we analyze and discuss the CSR character of British American Tobacco Switzerland. Our findings indicate that BAT Switzerland does not follow traditional patters of building CSR. BAT Switzerland can be classified as a “legitimacy seeker,” characterized mainly by a relational identity orientation and legitimation strategies that might provide pragmatic and/or cognitive legitimacy. We conclude that understanding the cognitive (...) processes underlying the CSR decision-making process is of fundamental value when analyzing and changing the CSR approach of a firm. We discuss boundary conditions of the CSR character framework and expand it by differentiating between process and product legitimacy, as both perspectives have important but possibly different implications for the firm. (shrink)

Pork producers in Western Europe moreand more encounter a variety of societalconcerns about pork and pork production. Sofar, however, producers predominantly focusedon low consumer prices, therewith addressingjust one concern. This resulted in an intensiveand large-scale production system, decreasinglyrelated to the area of farm land, andaccompanied with increasing concerns aboutsafety and healthiness of pork, animal welfare,environmental pollution, and others.An overview was given of possible concernsabout West-European pork production with theconsumers, citizens, and producers, and thoseconcerns are traced back to the pork productionsystem. (...) The various kinds and qualities ofinformation about the pork production system onwhich possible concerns are based have beenworked out extensively in this paper. Knowledgeabout the aspects of pork production that cangive rise to concerns can be used in two ways.First, the communication about those aspectstowards consumers and citizens can be adjustedor extended to give them better possibilitiesto make food choices or to develop their ownopinions about pork production. Second,producers could change the pork productionsystem such that it better satisfies consumersand citizens. Such adaptations are wellpossible, as three pork quality schemes, whichhave been evaluated, illustrate. However, mostof these adaptations can only be carried out atthe cost of the present low consumer prices andwill not occur spontaneously on a large scale.Therefore, accounting for the type andrelevance of the concerns, legislation isnecessary to address societal concerns in abalanced way such that pork production systemsbecome acceptable for the majority of oursociety. (shrink)

All species continuously evolve to adapt to changing environments. The genetic variation that fosters such adaptation is caused by a plethora of mechanisms, including meiotic recombination that generates novel allelic combinations in the progeny of two parental lineages. However, a considerable number of eukaryotic species, including many fungi, do not have an apparent sexual cycle and are consequently thought to be limited in their evolutionary potential. As such organisms are expected to have reduced capability to eliminate deleterious mutations, they are (...) often considered as evolutionary dead ends. However, inspired by recent reports we argue that such organisms can be as persistent as organisms with conventional sexual cycles through the use of other mechanisms, such as genomic rearrangements, to foster adaptation. (shrink)

We investigated spectral resting-state EEG in persons with chronic stroke-induced aphasia to determine its reliability, sensitivity, and relationship to functional behaviors. Resting-state EEG has not yet been characterized in this population and was selected given the demonstrated potential of resting-state investigations using other neuroimaging techniques to guide clinical decision-making. Controls and persons with chronic stroke-induced aphasia completed two EEG recording sessions, separated by approximately 1 month, as well as behavioral assessments of language, sensorimotor, and cognitive domains. Power in the classic (...) frequency bands was examined via spectral analysis of resting-state EEG data. Results suggest that power in the theta, alpha, and beta bands is reliable for use as a repeated measure. Significantly greater theta and lower beta power was observed in persons with aphasia than controls. Finally, in PWAs theta power negatively correlated with performance on a discourse informativeness measure, while alpha and beta power positively correlated with performance on the same measure. This indicates that spectral rsEEG slowing observed in PWAs in the chronic stage is pathological and suggests a possible avenue for directly altering brain activation to improve behavioral function. Taken together, these results suggest that spectral resting-state EEG holds promise for sensitive measurement of functioning and change in persons with chronic aphasia. Future studies investigating the utility of these measures as biomarkers of frank or latent aphasic deficits and treatment response in chronic stroke-induced aphasia are warranted. (shrink)

Transplantation research on samples and organs from deceased donors in England, Wales and Northern Ireland is under threat. The key problems relate to difficulties encountered in gaining consent for research projects, as distinct from consent to donation for clinical transplantation. They are due partly to the terms of the Human Tissue Act 2004 (the 2004 Act), and partly to its interpretation by the Human Tissue Authority (HTA). They include excessive interaction with donor representatives regarding ‘informed consent’ to research projects, uncertainty (...) as to the scope and duration of a donor's ‘authority’ over an organ, and restrictions caused by the apparent need for licensing of transplantation research under the 2004 Act, combined with lack of certainty, or guidance, as to the distinction between ‘research’, which requires a licence, and ‘service development’, which does not. In our view this confusion hinders and deters Specialist Nurses for Organ Donation in approaching donor representatives and discussing possible research projects with them. It has also, as we have reported elsewhere, led to abandonment of research projects for fear of liability, despite both Research Ethics Committee (REC) approval and donor consent. Such problems do not seem to occur under the transplant laws of most other comparable jurisdictions. The Transplantation Ethics Symposium, ‘The ethics of organ retrieval: goals, rights and responsibilities’, hosted by the MRC Centre for Transplantation at King's College London in December 2010, revealed that many senior clinicians and researchers, administrators, and lawyers are both unclear and in disagreement concerning the effects of the 2004 Act and the extent to which it is adhered to or ignored in practice. In this paper we examine the difficulties encountered and suggest solutions based on a less restrictive interpretation of the 2004 Act, or, more probably, a regulatory change under its authority. We propose that, in the long term, a law which includes consent for REC-approved research within the general consent for organ donation and transplantation seems preferable to the present system, both ethically and in practical terms. (shrink)

Graphical AbstractDriving patterns of coral bleaching over reefs are a suite of biophysical interactions where the physical environment modulates organism response through an interplay with intrinsic biological functioning. Flow conditions over reefs can mitigate the physiological impacts of thermal stress across multiple spatial scales. More details can be found in article number 1800226 by Charlotte E. Page et al., Seeking Resistance in Coral Reef Ecosystems: The Interplay of Biophysical Factors and Bleaching Resistance under a Changing Climate, DOI: 10.1002/bies.201800226.

© 2015 Elsevier Inc.Postnatal organogenesis occurs in an immune competent environment and is tightly controlled by interplay between positive and negative regulators. Innate immune cells have beneficial roles in postnatal tissue remodeling, but roles for the adaptive immune system are currently unexplored. Here we show that adaptive immune responses participate in the normal postnatal development of a non-lymphoid epithelial tissue. Since the mammary gland is the only organ developing predominantly after birth, we utilized it as a powerful system to study (...) adaptive immune regulation of organogenesis. We found that antigen-mediated interactions between mammary antigen-presenting cells and interferon-γ -producing CD4+ T helper 1 cells participate in MG postnatal organogenesis as negative regulators, locally orchestrating epithelial rearrangement. IFNγ then affects luminal lineage differentiation. This function of adaptive immune responses, regulating normal development, changes the paradigm for studying players of postnatal organogenesis and provides insights into immune surveillance and cancer transformation. Plaks et al. (shrink)

A number of recent books and articles have defended the concept of de re modality. Although Slote makes some contributions toward its defense, he is mainly concerned with using de re modality to provide analyses of key concepts in metaphysics, including "process", "event", "change", "physical body", "self", "future", "past", "fact", and "state of affairs". Each concept is defined by essence and accident, that is, by specifying what is either accidental or essential to the entities covered by the concept. Such definitions (...) focus on the ontological relationships of exact similarity, necessary coexistence, and logical dependence. They provide the necessary existence conditions for processes, events, selves, etc. These existence conditions are a major concern in metaphysical questions about the relationship between psychic and physical existence, selves and their experiences, and things and their alterations. Thus Slote provides an important analytical procedure for this type of metaphysical problem. (shrink)

Metabolic pathways underlying brain function remain largely unexplored during neurodevelopment, predominantly due to the lack of feasible techniques for use with awake infants. Broadband near-infrared spectroscopy provides the opportunity to explore the relationship between cerebral energy metabolism and blood oxygenation/haemodynamics through the measurement of changes in the oxidation state of mitochondrial respiratory chain enzyme cytochrome-c-oxidase alongside haemodynamic changes. We used a bNIRS system to measure ΔoxCCO and haemodynamics during functional activation in a group of 42 typically developing infants aged between (...) 4 and 7 months. bNIRS measurements were made over the right hemisphere over temporal, parietal and central cortical regions, in response to social and non-social visual and auditory stimuli. Both ΔoxCCO and Δ[HbO2] displayed larger activation for the social condition in comparison to the non-social condition. Integration of haemodynamic and metabolic signals revealed networks of stimulus-selective cortical regions that were not apparent from analysis of the individual bNIRS signals. These results provide the first spatially resolved measures of cerebral metabolic activity alongside haemodynamics during functional activation in infants. Measuring synchronised changes in metabolism and haemodynamics have the potential for uncovering the development of cortical specialisation in early infancy. (shrink)

The changing sacred landscape of Late Antiquity has long been seen in terms of a monolithic development ‘from temple to church’. Recent scholarship, however, has discarded this picture in favour of a more complex view, in which freestanding churches (and monasteries) were increasingly built from the fourth century onwards, while at the same time various, mostly practical, ways were found of dealing with the sacred built environment of the past. The Late Antique papyri from Oxyrhynchus contain dozens of references to (...) churches and monasteries, and, occasionally, also temples. The city thus affords an excellent opportunity to study the changing sacred landscape of this period in a local context. In previous scholarship, several lists have been compiled to collect the attestations of churches. The last comprehensive collection of the material dates back two decades, however, while the one list of monasteries is heavily outdated. Moreover, a list of temples in the Late Antique papyri has never been put together. This article, then, presents, in the appendix, a brand-new Checklist of temples, churches and monasteries of Late Antique Oxyrhynchus. It serves as the basis for the detailed analysis of the data that precedes it, which shows that these data are in perfect agreement with the now prevalent general view among Late Antique scholars of how the sacred landscape changed over time. For comparison with the findings from the papyri, we will also briefly discuss the results of recent excavations at the site. (shrink)

The argument of this book is that there is a form of Christian philosophy congruent with the contemporary philosophical climate. According to the author, a philosophy is Christian to the extent that it is elaborated within a Christian Weltanschauung, that is, insofar as its spirit and fundamental contents are guided by Christian revelation and bear the impress of Christian redemption. Christian philosophy is not a single system, but rather a tradition which approaches philosophical problems from a Christian perspective. Within this (...) tradition there can exist a considerable variety of philosophical opinion, since Christian revelation leaves many questions undecided. To show that such a Christian philosophy is possible today the author spends the major part of the book surveying a number of currents in recent philosophy. One purpose of this survey is to examine the resources and weaknesses of various philosophical methodologies. More importantly, the survey is used as the basis for arguing that existentialism, phenomenology, and analytic philosophy have recently developed in directions which suggest the possibility of formulating a new metaphysics which is at once contemporary and compatible with Christian philosophy as the author understands it. This new metaphysics is one which steers a middle ground between dogmatism and relativism. It is at once synoptic, in that it seeks a coherent understanding of the whole of reality by filling in the gaps in individual and collective experience; categorial, in that it forges categories which "picture the pervasive and formative characteristics of the world which are indicated by the large-scale structural aspects of experience and language rather than by particular observations or individual terms"; perspectival, in the sense that such a metaphysics elaborates a view of the world judged adapted to the philosopher's basic human commitments, to the empirical facts, and to formal laws of coherence and consistency, but in such a way that it remains open to changing attitudes and insights. Though its basic argument is not hard to grasp, this book is not easy to read. Partially this is due to a rather plodding style, but primarily it is the result of the structure of the book, which is such that the author discourses at a level of considerable generality on the doctrines of a great many different philosophers. He does this partially in order to illustrate his understanding of the dialogical character of philosophy. Nevertheless, the author's aims might well have been better served by a briefer, more sharply honed argument.--H. F. (shrink)

The ‘What Being the Parent of a New Baby is Like-Revised’ is an instrument designed to measure adaptation to parenthood. In the process of pilot testing and validating the WPL-R in a postpartum Dutch population, we became aware of the potentially sensitive nature of the measure. Despite the ethics committee waiving the invasive nature of the measure, we conducted a survey to explore its possible effect on women’s thoughts and emotions by using the Positive And Negative Affect Schedule to measure (...) changes associated with completion of the WPL-R. Two hundred and fifteen questionnaires were returned. Our findings indicated a change in PANAS scores, implying an intervening effect when using the WPL-R, in research. This raises the question of whether it is acceptable to use a questionnaire with postpartum women without any knowledge of the possible effect it may have, even though the ethics committee has approved the study and considers the measure to be non-invasive. (shrink)

We report specific heat and μSR measurements on Th and/or B substituted UBe13. The specific heat data show that either Th or B substitution reduces the Kondo temperature TK and increases the entropy at the superconducting transition by almost 20%, indicating an enhanced density of states. However, whereas μSR shows clear evidence for magnetic correlations for Th substitutions, no magnetism is observed for B substitutions. The enhanced specific heat jump in the B-substituted material is associated with a change in the (...) superconducting properties as TK is reduced. (shrink)

In a qualitative study, 22 stroke patients undergoing rehabilitation in three nursing homes were interviewed about constraints on and improvements in their autonomy and about approaches of health professionals regarding autonomy. The data were analysed using grounded theory, with a particular focus on the process of regaining autonomy. An approach by the health professionals that was responsive to changes in the patients’ autonomy was found to be helpful for restoration of their autonomy. Two patterns in health professionals’ approach appeared to (...) be facilitatory: (1) from full support on admission through moderate support and supervision, to reduced supervision at discharge; and (2) from paternalism on admission through partial paternalism (regarding treatment) to shared decision making at discharge. The approach experienced by the patients did not always match their desires regarding their autonomy. Support and supervision were reduced over time, but paternalism was often continued too long. Additionally, the patients experienced a lack of information. Tailoring interventions to patients’ progress in autonomy would stimulate their active participation in rehabilitation and in decision making, and would improve patients’ preparation for autonomous living after discharge. (shrink)

IPCC SPECIAL REPORT ON CLIMATE CHANGE AND LAND (SRCCL) -/- Chapter 3: Climate Change and Land: An IPCC special report on climate change, desertification, land degradation, sustainable land management, food security, and greenhouse gas fluxes in terrestrial ecosystems.

This book contains three essays: "The Mask and the Face: The Perception of Physiognomic Likeness in Life and Art" by Gombrich, the renowned art historian and critic; "The Representation of Things and People" by psychologist, Julian Hochberg; and "How Do Pictures Represent" by philosopher, Max Black. The book is based upon lectures delivered in the Johns Hopkins 1970 Thalheimer Lectures, where, taking off from the question "how there can be an underlying identity in the manifold and changing facial expression of (...) a single individual," there is an interdisciplinary attempt at clarifying the problem of representation. Gombrich’s central thesis is that the key to artistic representation is empathy and projection, which is guided by the interlocking display of the permanent and mobile features of the object represented. Perceptual activity and empathy rely more on the muscular imitation than on passive visual reception. He holds that what is singled out as the likeness-factor uniting the permanent and mobile features in, for example, the photograph of the four-year old Lord Russell and such factors in the ninety-year old Russell is the "general tonus, the melody of transition from given ranges of relaxations to forms of tenseness." Hochberg’s essay spells out the position that perception is purposive behavior, wherein the purpose is the information sought and behavior is the "succession of glances in different directions." Holding that perceptual activity is grounded in expectations, he lays aside Gombrich’s muscularity-thesis in favor of a learned expectation of feature characteristics. Black’s essay is a conceptual analysis of "depiction," or more precisely, of "P displays a subject S if and only if R, where R ‘will constitute the necessary and sufficient condition for P displaying S'." The essay, which proceeds in a Wittgensteinian Investigations-type fashion ends where the reader would hope it begin. He concludes that the problem can only be adequately answered by moving from logical investigation to the world of the artisan and art lover. To arrive at this conclusion he debunks six candidates that claim to meet the depiction conditions: causal history, selective information, intention, mimesis, resemblance, and "looking-like." At best, depiction may be considered a "cluster" concept of all six. Further determination, he holds, requires knowledge of the purpose of a particular depiction, and this takes us out of logic and into art; and so Black stops, unfortunately.—W. A. F. (shrink)